When AntiVirus software is running on the ProjectWise Design Integration Server computer, it locks the DMSKRNL.CFG, therefore you may notice that on occasion, you cannot create a datasource or make certain modifications to existing ones. If you run into this issue, either wait for the AntiVirus software to finish its virus check before you start editing the DMSKRNL.CFG file, or turn off AntiVirus while you are editing the DMSKRNL.CFG file.